Article
Complete nucleotide sequence and viral envelope protein expression of a hepatitis B virus DNA derived from a hepatitis B surface antigen-seronegative patient.
Journal of hepatology - 1 Jun 1993
Kremsdorf D, Garreau F, Duclos H, Thiers V, Schellekens H, Petit M A, Bréchot C
Abstract excerpt
An HBV strain isolated from a patient lacking conventional serological markers of HBV infection was characterized. The complete nucleotide sequence was determined following PCR amplification. Only 22 nucleotide substitutions were found relative to the reported sequence of the ayw subtype. Five of these point mutations in the preS/S and preC/C genes led to amino acid substitutions and, with one exception, were...
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