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Article

Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis

1 Mar 1994

Abstract excerpt

Hepatitis B virus (HBV) mutants unable to synthesize HBV e antigen have been described in association with fulminant hepatitis. We have cloned and sequenced the entire viral genome of an HBV strain associated with an epidemic of fulminant hepatitis. This strain contained, in addition to two G-to-A mutations in the precore region (nucleotides 1898 and 1901), numerous other mutations in conserved nucleotide...

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PMID: 8107226
DOI: 10.1128/jvi.68.3.1651-1659.1994

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