Article
Interaction of wild-type and naturally occurring deleted variants of hepatitis B virus core polypeptides leads to formation of mosaic particles.
FEBS letters - 28 Jul 2000
Preikschat P, Kazaks A, Dishlers A, Pumpens P, Krüger D H, Meisel H
Abstract excerpt
The simultaneous presence of hepatitis B virus (HBV) genomes carrying wild-type (wt) and in-frame deleted variants of the HBV core gene has been identified as a typical feature of HBV-infected renal transplant patients with severe liver disease. To investigate possible interactions of wt and deleted core polypeptides a two-vector Escherichia coli expression system ensuring their concomitant synthesis has been...
Topics
- Blotting, Western
- Dimerization
- Escherichia coli
- Genetic Variation
- Hepatitis B Core Antigens
- Hepatitis B virus
- Immunodominant Epitopes
- Microscopy, Electron
- Peptides
- Precipitin Tests
- Protein Binding
- Protein Structure, Quaternary
- Recombinant Proteins
- Sequence Deletion