Article
Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region.
Gastroenterology - 1 Oct 1990
Akahane Y, Yamanaka T, Suzuki H, Sugai Y, Tsuda F, Yotsumoto S, Omi S, Okamoto H, Miyakawa Y, Mayumi M
Abstract excerpt
Some patients with type B chronic active hepatitis have a high titer of hepatitis B virus DNA despite antibody against e antigen in the serum. Clones of hepatitis B virus were propagated from the sera of seven patients with this disease, and the precore region was sequenced. Essentially all clone...
Topics
- Aged
- Amino Acid Sequence
- Base Sequence
- DNA Mutational Analysis
- DNA, Viral
- Hepatitis B
- Hepatitis B Antibodies
- Hepatitis B e Antigens
- Hepatitis B virus
- Hepatitis, Chronic
- Humans
- Liver
- Male
- Middle Aged