Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.

Journal of virology - 1 May 2012

Shukla P, Nguyen H T, Faulk K, Mather K, Torian U, Engle R E, Emerson S U

Abstract excerpt

An infectious cDNA clone of a genotype 3 strain of hepatitis E virus adapted to growth in HepG2/C3A human hepatoma cells was constructed. This virus was unusual in that the hypervariable region of the adapted virus contained a 171-nucleotide insertion that encoded 58 amino acids of human S17 ribosomal protein. Analyses of virus from six serial passages indicated that genomes with this insert, although initially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Hepatitis E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis E virus

Share to Molecular Sequence Data

Share to Mutagenesis, Insertional

Share to Recombination, Genetic

Share to Ribosomal Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22398290
DOI: 10.1128/JVI.00146-12
PMCID: PMC3347312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.PMID 22398290Read ↗

The Lysine Residues within the Human Ribosomal Protein S17 Sequence Naturally Inserted into the Viral Nonstructural Protein of a Unique Strain of Hepatitis E Virus Are Important for Enhanced Virus ReplicationSemantic proximity Read ↗

Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant.Semantic proximity Read ↗

Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.Semantic proximity Read ↗

Natural selection of adaptive mutations in non-structural genes increases trans-encapsidation of hepatitis C virus replicons lacking envelope protein genes.Semantic proximity Read ↗

An <scp>ORF</scp>1‐rearranged hepatitis <scp>E</scp> virus derived from a chronically infected patient efficiently replicates in cell cultureSemantic proximity Read ↗

Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations.Semantic proximity Read ↗

Molecular evolution of hepatitis A virus in a human diploid cell line.Semantic proximity Read ↗

Generation of a cell culture-adapted hepatitis C virus with longer half life at physiological temperature.Semantic proximity Read ↗

The Envelope Gene of Hepatitis B Virus Is Implicated in Both Differential Virion Secretion and Genome Replication Capacities between Genotype B and Genotype C Isolates.Semantic proximity Read ↗

A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo.Semantic proximity Read ↗

Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted VariantSemantic proximity Read ↗

Attenuated hepatitis A virus: genetic determinants of adaptation to growth in MRC-5 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.