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Article

Hepatitis B envelope protein mutants in human hepatocellular carcinoma tissues.

Journal of viral hepatitis - 1 May 1999

Zhong S, Chan J Y, Yeo W, Tam J S, Johnson P J

Abstract excerpt

Hepatitis B virus (HBV) envelope mutants in the region encoding the highly immunogenic major hydrophilic region (MHR) of surface antigen (HBsAg) have been associated with vaccine failure and chronic infection. To determine if these mutants are associated with the development of human hepatocellular carcinoma (HCC), we measured the frequency and nature of such mutants in 23 HBV-associated HCC and various control...

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PMID: 10607231
DOI: 10.1046/j.1365-2893.1999.00154.x

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