Article
Hepatitis B envelope protein mutants in human hepatocellular carcinoma tissues.
Journal of viral hepatitis - 1 May 1999
Zhong S, Chan J Y, Yeo W, Tam J S, Johnson P J
Abstract excerpt
Hepatitis B virus (HBV) envelope mutants in the region encoding the highly immunogenic major hydrophilic region (MHR) of surface antigen (HBsAg) have been associated with vaccine failure and chronic infection. To determine if these mutants are associated with the development of human hepatocellul...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Blotting, Southern
- Carcinoma, Hepatocellular
- Child
- Female
- Hepatitis B
- Hepatitis B virus
- Humans
- Liver Neoplasms
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sequence Analysis, DNA
- Viral Envelope Proteins