Article
Selection of hepatitis B surface "escape" mutants during passive immune prophylaxis following liver transplantation: potential impact of genetic changes on polymerase protein function.
Gut - 1 Aug 1999
Shields P L, Owsianka A, Carman W F, Boxall E, Hubscher S G, Shaw J, O'Donnell K, Elias E, Mutimer D J
Abstract excerpt
CASE REPORT: A patient is described who developed hepatitis B virus (HBV) reinfection five months following liver transplantation. Failure of hepatitis B immunoglobulin prophylaxis was associated with the emergence of mutations. HBV gene sequencing identified nucleotide substitutions associated with amino acid changes, one within the major hydrophilic region (MHR) of the HBV surface antigen at amino acid position...
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