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Article

Molecular analysis of antigenicity and immunogenicity of a vaccine-induced escape mutant of hepatitis B virus.

Journal of gastroenterology - 1 Jan 2003

Shizuma Toru, Hasegawa Kiyoshi, Ishikawa Kayo, Naritomi Takuma, Iizuka Aiko, Kanai Naoko, Ogawa Miho, Torii Nobuyuki, Joh Riho, Hayashi Naoaki

Abstract excerpt

BACKGROUND: To analyze the mechanisms of mutant escape, we established a murine model of hepatitis B virus (HBV) infection and studied the interaction of the envelope protein of the virion with various kinds of anti-hepatitis B antibody. METHODS: Mutation from glycine to arginine at aa145 was introduced into replication-competent DNA of HBV. The resulting mutant HBV DNA was transfected into cultured hepatoma...

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Identifiers

PMID: 12673447
DOI: 10.1007/s005350300043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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