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Article

High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen‐driven immune responses

1 Mar 1996

Abstract excerpt

OBJECTIVE: To investigate T cell antigen receptor (TCR) clonotypes in rheumatoid arthritis (RA) lesions. METHODS: Reverse transcriptase-polymerase chain reaction with TCR V beta family-specific primers and subsequent single-strand conformation polymorphism (SSCP) analysis were performed. Direct nucleotide sequencing was also conducted. RESULTS: A distinct clonal expansion of T cells was observed in the synovium....

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PMID: 8607893
DOI: 10.1002/art.1780390312

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