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Article

Diversity of rheumatoid synovial tissue T cells by T cell receptor analysis. Oligoclonal expansion in interleukin-2-responsive cells.

Arthritis and rheumatism - 1 May 1991

Cooper S M, Dier D L, Roessner K D, Budd R C, Nicklas J A

Abstract excerpt

The synovitis of rheumatoid arthritis (RA) is characterized by infiltrates of CD4+ T lymphocytes. To determine the clonal diversity of these cells, we cloned T cells with interleukin-2 (IL-2), alone or with phytohemagglutinin (PHA), directly from actively inflamed synovial tissue obtained at synovectomy. A total of 205 clones from 4 specimens was analyzed for T cell receptor (TCR) gene rearrangements using Hind...

Topics

Adult
Arthritis, Rheumatoid
Cell Division
Clone Cells
Female
Humans
Interleukin-2
Male
Middle Aged
Phenotype
Receptors, Antigen, T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Synovial Membrane

T-Lymphocytes

Source

Identifiers

PMID: 2025307
DOI: 10.1002/art.1780340505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2025307-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Diversity of rheumatoid synovial tissue T cells by T cell receptor analysis. Oligoclonal expansion in interleukin-2-responsive cells.PMID 2025307Read ↗

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