Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.

doi:10.1073/pnas.88.23.10921

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Article

Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1991

Howell M D, Diveley J P, Lundeen K A, Esty A, Winters S T, Carlo D J, Brostoff S W

Abstract excerpt

Rheumatoid arthritis (RA) is a disease affecting the synovial membranes of articulating joints that is thought to result from T-cell-mediated autoimmune phenomena. T cells responsible for the pathogenesis of RA are likely present in that fraction of synovial T cells that expresses the interleukin 2 receptor (IL-2R), one marker of T-cell activation. We report herein an analysis of T-cell receptor (TCR) beta-chain...

Topics

Alleles
Amino Acid Sequence
Animals
Arthritis, Rheumatoid
Base Sequence
Cloning, Molecular
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Genetic Variation
HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Macromolecular Substances

Mice

Molecular Sequence Data

Nucleic Acid Hybridization

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Receptors, Antigen, T-Cell

Receptors, Antigen, T-Cell, alpha-beta

Source

Open in PubMed Open full text

Identifiers

PMID: 1660155
DOI: 10.1073/pnas.88.23.10921
PMCID: PMC53044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1660155-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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