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Article

Rheumatoid factor isotype switch and somatic mutation variants within rheumatoid arthritis synovium.

Immunology - 1 Sept 1999

Williams D G, Moyes S P, Mageed R A

Abstract excerpt

The presence of clonally-related B-lymphocyte aggregates within synovial lining tisue of rheumatoid arthritis (RA) patients suggests a germinal centre-like reaction, which may hold implications for disease pathogenesis and the causes of chronic inflammation. We studied 250 rheumatoid factor (RF) heavy-chain sequences cloned from the synovium of three patients with RA, to determine whether they undergo both...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10469243
DOI: 10.1046/j.1365-2567.1999.00841.x
PMCID: PMC2326907

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Source receipt: pubmed, retrieved 7 Sept 2026.

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