Article
Aberrations in the primary T-cell receptor repertoire as a predisposition for synovial inflammation in rheumatoid arthritis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 May 1999
Yang H, Rittner H, Weyand C M, Goronzy J J
Abstract excerpt
BACKGROUND: Rheumatoid arthritis (RA) is an HLA-DR associated disease with a pivotal role of T cells in the pathogenesis. The mechanisms underlying the HLA association and the generation of a synovial T-cell response are unclear. We have hypothesized that the selection of the primary T-cell repertoire is a predisposing factor for rheumatoid synovitis. METHODS: The repertoire of T-cell receptors (TCR) expressed by...
Topics
- Alleles
- Arthritis, Rheumatoid
- Base Sequence
- CD4-Positive T-Lymphocytes
- Case-Control Studies
- DNA Primers
- Gene Frequency
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Receptors, Antigen, T-Cell
- Synovitis