Article
Alterations of the synovial T cell repertoire in anti-citrullinated protein antibody-positive rheumatoid arthritis.
Arthritis and rheumatism - 1 Jul 2009
Cantaert Tineke, Brouard Sophie, Thurlings Rogier M, Pallier Annaick, Salinas Gabriela Franco, Braud Christophe, Klarenbeek Paul L, de Vries Niek, Zhang Yiping, Soulillou Jean-Paul, Tak Paul P, Baeten Dominique
Abstract excerpt
OBJECTIVE: The association of HLA-DRB1 alleles with anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) suggests the potential involvement of T lymphocytes in ACPA-seropositive disease. The purpose of this study was to investigate this hypothesis by systematic histologic and molecular analyses of synovial T cells in ACPA+ versus ACPA- RA patients. METHODS: Synovial biopsy samples were...
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