Article
Intracellular transactivation of the insulin-like growth factor I receptor by an epidermal growth factor receptor.
Experimental cell research - 15 Mar 1996
Burgaud J L, Baserga R
Abstract excerpt
Growth factor receptors may be transactivated not only by homologous receptors, but also by heterologous receptors. We have investigated this possibility, using for this purpose R-/EGFR cells, which are mouse embryo cells devoid of IGF-I receptors, but overexpressing the EGF receptor. At variance...
Topics
- Adenosine Triphosphate
- Animals
- Binding Sites
- Cell Division
- Cell Line
- Cell Transformation, Viral
- Epidermal Growth Factor
- ErbB Receptors
- Humans
- Insulin-Like Growth Factor I
- Mice
- Mutation
- Phenotype
- Phosphorylation
- Protein-Tyrosine Kinases
- Receptor, IGF Type 1
- Transcriptional Activation