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Article

SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation.

Journal of cellular physiology - 1 Oct 2017

Lin Yingbo, Liu Hongyu, Waraky Ahmed, Haglund Felix, Agarwal Prasoon, Jernberg-Wiklund Helena, Warsito Dudi, Larsson Olle

Abstract excerpt

Increasing number of studies have shown nuclear localization of the insulin-like growth factor 1 receptor (nIGF-1R) in tumor cells and its links to adverse clinical outcome in various cancers. Any obvious cell physiological roles of nIGF-1R have, however, still not been disclosed. Previously, we reported that IGF-1R translocates to cell nucleus and modulates gene expression by binding to enhancers, provided that...

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Identifiers

PMID: 28112398
DOI: 10.1002/jcp.25818
PMCID: PMC5518303

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