Article
Insulin-like growth factor I (IGF-I) receptor overexpression abolishes the IGF requirement for differentiation and induces a ligand-dependent transformed phenotype in C2 inducible myoblasts.
Endocrinology - 1 Dec 1997
Navarro M, Barenton B, Garandel V, Schnekenburger J, Bernardi H
Abstract excerpt
Insulin-like growth factors (IGFs) stimulate both proliferation and differentiation of myogenic cell lines, and these actions are mostly mediated through the type I IGF receptor (type I IGF-R). To further investigate the role of this receptor in phenotypic characteristics of C2 murine myoblasts,...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Differentiation
- Cells, Cultured
- Humans
- Insulin-Like Growth Factor I
- Ligands
- Mice
- Muscles
- Phenotype
- Receptors, Somatomedin