Article
Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor.
The Journal of biological chemistry - 24 May 1996
Li S, Resnicoff M, Baserga R
Abstract excerpt
The insulin-like growth factor I receptor (IGF-IR) controls the extent of cell proliferation in a variety of cell types by at least 3 different ways: it is mitogenic, it causes transformation, and it protects cells from apoptosis. Previous reports indicated that certain domains in the C terminus...
Topics
- Animals
- Base Sequence
- Cell Line, Transformed
- Cells, Cultured
- DNA Primers
- Mice
- Mitogens
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Phosphotransferases (Alcohol Group Acceptor)
- Rats
- Receptor, IGF Type 1
- Serine
- Signal Transduction
- Substrate Specificity