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Article

The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of Fibroblasts

1 Dec 1997

Abstract excerpt

Ewing's family of tumors is characterized by a well described reciprocal translocation, t(11;22)(q24;q12), which produces a fusion protein (EWS/FLI-1) that transforms mouse fibroblasts. The EWS/FLI-1 fusion protein has been shown to act as a potent chimeric transcription factor. Overexpression of insulin-like growth factor-I receptor (IGF-IR) has been implicated in many tumor models as playing a role in cell...

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Identifiers

PMID: 9388225
DOI: 10.1074/jbc.272.49.30822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of FibroblastsPMID 9388225Read ↗

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.Semantic proximity Read ↗

Intracellular transactivation of the insulin-like growth factor I receptor by an epidermal growth factor receptor.Semantic proximity Read ↗

Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathwaySemantic proximity Read ↗

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.Semantic proximity Read ↗

Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.Semantic proximity Read ↗

Transforming potential of the insulin receptor substrate 1.Semantic proximity Read ↗

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma.Semantic proximity Read ↗

YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cellsSemantic proximity Read ↗

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.Semantic proximity Read ↗

Alteration of Mesodermal Cell Differentiation by EWS / FLI - 1 , the Oncogene Implicated in Ewing's SarcomaSemantic proximity Read ↗

EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells.Semantic proximity Read ↗

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaSemantic proximity Read ↗

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