Article
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.
Molecular and cellular biology - 1 Jun 1994
Sell C, Dumenil G, Deveaud C, Miura M, Coppola D, DeAngelis T, Rubin R, Efstratiadis A, Baserga R
Abstract excerpt
Fibroblast cell lines, designated R- and W cells, were generated, respectively, from mouse embryos homozygous for a targeted disruption of the Igf1r gene, encoding the type 1 insulin-like growth factor receptor, and from their wild-type littermates. W cells grow normally in serum-free medium supp...
Topics
- Animals
- Cell Cycle
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cells, Cultured
- Embryo, Mammalian
- Epidermal Growth Factor
- Genes, ras
- Growth Substances
- Insulin
- Insulin-Like Growth Factor I
- Kinetics
- Mice