Article
Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1992
Cullen K J, Lippman M E, Chow D, Hill S, Rosen N, Zwiebel J A
Abstract excerpt
It has been proposed that the insulin-like growth factors (IGFs) can act as autocrine and/or paracrine growth promoters in breast cancer. To investigate this hypothesis, we infected early passage MCF-7 cells with a retroviral vector containing the coding sequence for the IGF-II preprohormone along with a constitutive cytomegalovirus promoter sequence. These cells do not normally express IGF-I or IGF-II. After...
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