Article
Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1992
Cullen K J, Lippman M E, Chow D, Hill S, Rosen N, Zwiebel J A
Abstract excerpt
It has been proposed that the insulin-like growth factors (IGFs) can act as autocrine and/or paracrine growth promoters in breast cancer. To investigate this hypothesis, we infected early passage MCF-7 cells with a retroviral vector containing the coding sequence for the IGF-II preprohormone along with a constitutive cytomegalovirus promoter sequence. These cells do not normally express IGF-I or IGF-II. After...
Topics
- Breast Neoplasms
- Cell Adhesion
- Cell Division
- Cell Transformation, Neoplastic
- Estrogens
- Female
- Genetic Vectors
- Humans
- Insulin-Like Growth Factor II
- Phenotype
- RNA, Messenger