Article
Transforming potential of the insulin receptor substrate 1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1995
D'Ambrosio C, Keller S R, Morrione A, Lienhard G E, Baserga R, Surmacz E
Abstract excerpt
The role of the insulin receptor substrate 1 (IRS-1) in cellular transformation was studied in R- cells, which are 3T3-like fibroblasts derived from mouse embryos with a targeted disruption of the insulin-like growth factor I receptor gene. These cells cannot be transformed by oncogenes that read...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Blotting, Western
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Humans
- Insulin
- Insulin Receptor Substrate Proteins
- Insulin-Like Growth Factor I
- Mice
- Phenotype
- Phosphoproteins
- RNA, Antisense
- Signal Transduction
- Transcriptional Activation