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Article

Transforming potential of the insulin receptor substrate 1.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1995

D'Ambrosio C, Keller S R, Morrione A, Lienhard G E, Baserga R, Surmacz E

Abstract excerpt

The role of the insulin receptor substrate 1 (IRS-1) in cellular transformation was studied in R- cells, which are 3T3-like fibroblasts derived from mouse embryos with a targeted disruption of the insulin-like growth factor I receptor gene. These cells cannot be transformed by oncogenes that readily transform cells originating from wild-type littermate embryos (or other 3T3-like cells). In the present study, we...

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PMID: 7647039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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