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Article

Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor.

Oncogene - 21 Mar 1996

Hongo A, D'Ambrosio C, Miura M, Morrione A, Baserga R

Abstract excerpt

THe type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in mitogenesis and transformation. It has been previously shown that mitogenic signaling and transforming activity of the IGF-IR can be dissociated: a receptor truncated at residue 1229 (C-terminus) is fully mitogenic, in terms of its response to IGF-I, but cannot transform 3T3-like cells that are devoid of endogenous IGF-IRs (R-...

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PMID: 8649825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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