Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

The Journal of biological chemistry - 23 Dec 1994

Li S, Ferber A, Miura M, Baserga R

Abstract excerpt

We have investigated the effect of mutations in tyrosines 1131, 1135, and 1136 of the human insulin-like growth factor-I receptor (IGF-IR) on the growth and transformation of mammalian cells. We have used for this purpose R- cells, which are 3T3-like fibroblasts derived from mouse embryos with a targeted disruption of the IGF-IR genes. These cells have no IGF-IR, do not grow in serum-free medium supplemented with...

Topics

3T3 Cells
Animals
Base Sequence
Cell Adhesion
Cell Division
Cell Line
Cell Transformation, Neoplastic
Culture Media, Serum-Free
DNA
DNA Primers
Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin Receptor Substrate Proteins

Mice

Mice, Knockout

Mitogens

Molecular Sequence Data

Mutation

Phosphoproteins

Source

Open in PubMed

Identifiers

PMID: 7798258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7798258-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.PMID 7798258Read ↗

Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor.Semantic proximity Read ↗

Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.Semantic proximity Read ↗

Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.Semantic proximity Read ↗

Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor.Semantic proximity Read ↗

Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor.Semantic proximity Read ↗

Transforming potential of the insulin receptor substrate 1.Semantic proximity Read ↗

Interaction of 14-3-3 proteins with the insulin-like growth factor I receptor (IGFIR): evidence for a role of 14-3-3 proteins in IGFIR signaling.Semantic proximity Read ↗

Intracellular transactivation of the insulin-like growth factor I receptor by an epidermal growth factor receptor.Semantic proximity Read ↗

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.Semantic proximity Read ↗

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.Semantic proximity Read ↗

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.Semantic proximity Read ↗

Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.