Article
Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation.
Molecular and cellular biology - 1 Oct 1998
Li W, Jiang Y X, Zhang J, Soon L, Flechner L, Kapoor V, Pierce J H, Wang L H
Abstract excerpt
To investigate the potential role of protein kinase C-delta (PKC-delta) in insulin-like growth factor I receptor (IGF-IR)-mediated cell transformation, an oncogenic gag-IGF-IR beta-fusion receptor lacking the entire extracellular domain, which was designated NM1, and a full-length IGF-IR were coe...
Topics
- 3T3 Cells
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Enzyme Activation
- Gene Expression
- Gene Products, gag
- Isoenzymes
- Mice
- Mutation
- Phosphorylation
- Protein Kinase C
- Protein Kinase C-delta
- Protein-Tyrosine Kinases
- Receptor, IGF Type 1