Article
Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation.
Molecular and cellular biology - 1 Oct 1998
Li W, Jiang Y X, Zhang J, Soon L, Flechner L, Kapoor V, Pierce J H, Wang L H
Abstract excerpt
To investigate the potential role of protein kinase C-delta (PKC-delta) in insulin-like growth factor I receptor (IGF-IR)-mediated cell transformation, an oncogenic gag-IGF-IR beta-fusion receptor lacking the entire extracellular domain, which was designated NM1, and a full-length IGF-IR were coexpressed with either wild-type PKC-delta (PKC-deltaWT) or an ATP-binding mutant of PKC-delta (PKC-deltaK376R) in NIH...
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