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Article

Genetic variation of the poliovirus genome with two VPg coding units.

The EMBO journal - 2 Jan 1996

Cao X, Wimmer E

Abstract excerpt

Amongst the picornaviruses, poliovirus encodes a single copy of the genome-linked protein, VPg wheras foot-and-mouth disease virus uniquely encodes three copies of VPg. We have previously shown that a genetically engineered poliovirus genome containing two tandemly arranged VPgs is quasi-infectious (qi) that, upon genome replication, inadvertently deleted one complete VPg sequence. Using two genetically marked...

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Identifiers

PMID: 8598203
PMCID: PMC449914

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