Article
Determinants of the VP1/2A junction cleavage by the 3C protease in foot-and-mouth disease virus-infected cells.
The Journal of general virology - 1 Mar 2017
Kristensen Thea, Normann Preben, Gullberg Maria, Fahnøe Ulrik, Polacek Charlotta, Rasmussen Thomas Bruun, Belsham Graham J
Abstract excerpt
The foot-and-mouth disease virus (FMDV) capsid precursor, P1-2A, is cleaved by FMDV 3C protease to yield VP0, VP3, VP1 and 2A. Cleavage of the VP1/2A junction is the slowest. Serotype O FMDVs with uncleaved VP1-2A (having a K210E substitution in VP1; at position P2 in cleavage site) have been des...
Topics
- 3C Viral Proteases
- Amino Acid Substitution
- Animals
- Antiviral Agents
- Capsid
- Capsid Proteins
- Cysteine Endopeptidases
- Drug Evaluation, Preclinical
- Foot-and-Mouth Disease
- Foot-and-Mouth Disease Virus
- Glutamic Acid
- Lysine
- Mutation
- Viral Proteins
- Virus Assembly