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Article

Determinants of the VP1/2A junction cleavage by the 3C protease in foot-and-mouth disease virus-infected cells.

The Journal of general virology - 1 Mar 2017

Kristensen Thea, Normann Preben, Gullberg Maria, Fahnøe Ulrik, Polacek Charlotta, Rasmussen Thomas Bruun, Belsham Graham J

Abstract excerpt

The foot-and-mouth disease virus (FMDV) capsid precursor, P1-2A, is cleaved by FMDV 3C protease to yield VP0, VP3, VP1 and 2A. Cleavage of the VP1/2A junction is the slowest. Serotype O FMDVs with uncleaved VP1-2A (having a K210E substitution in VP1; at position P2 in cleavage site) have been described previously and acquired a second site substitution (VP1 E83K) during virus rescue. Furthermore, introduction of...

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Identifiers

PMID: 27902359
DOI: 10.1099/jgv.0.000664
PMCID: PMC5797948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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