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Article

Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.

PLoS pathogens - 1 Oct 2017

Herod Morgan R, Gold Sarah, Lasecka-Dykes Lidia, Wright Caroline, Ward Joseph C, McLean Thomas C, Forrest Sophie, Jackson Terry, Tuthill Tobias J, Rowlands David J, Stonehouse Nicola J

Abstract excerpt

The RNA genomes of picornaviruses are translated into single polyproteins which are subsequently cleaved into structural and non-structural protein products. For genetic economy, proteins and processing intermediates have evolved to perform distinct functions. The picornavirus precursor protein, P3, is cleaved to produce membrane-associated 3A, primer peptide 3B, protease 3Cpro and polymerase 3Dpol. Uniquely,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28968463
DOI: 10.1371/journal.ppat.1006666
PMCID: PMC5638621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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