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Article

Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses.

Journal of neuropathology and experimental neurology - 1 Sept 2000

Saunders A M

Abstract excerpt

Exceptional advances have been made in understanding the genetics of how common polymorphisms of the apolipoprotein E gene influence the risk and age of onset of Alzheimer disease (AD). The major genetic susceptibility locus for the common forms of AD, there are 3 common alleles, designated epsilon2, epsilon3, and epsilon4. The inheritance of each dose of APOE4 increases the risk of disease and decreases the age...

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Identifiers

PMID: 11005255
DOI: 10.1093/jnen/59.9.751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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