Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease.

doi:10.1001/archneur.55.7.1001

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Article

Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease.

Archives of neurology - 1 Jul 1998

McNamara M J, Gomez-Isla T, Hyman B T

Abstract excerpt

OBJECTIVE: To examine the differential deposition of amyloid beta (Abeta) peptide isoforms Abeta40 and Abeta42 in the Alzheimer disease (AD) brain in relation to the apolipoprotein E (APOE) genotype. BACKGROUND: The APOE epsilon4 genotype is an inherited risk factor for AD and is associated with...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Amyloid beta-Peptides
Apolipoproteins E
Female
Genotype
Humans
Male
Middle Aged
Neuropeptides
Peptide Fragments
Plaque, Amyloid

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