Article
APOE epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of A beta protein.
Neuropathology and applied neurobiology - 1 Jun 2003
Chalmers K, Wilcock G K, Love S
Abstract excerpt
The relative amounts of amyloid beta-protein (A beta) in cerebral blood vessels and parenchyma vary considerably amongst patients with Alzheimer's disease (AD). Although several mechanisms have been proposed to explain this variability, the underlying genetic and environmental determinants are still unclear, as are the functional consequences. Polymorphisms in APOE, the gene for apolipoprotein E (ApoE), influence...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E4
- Apolipoproteins E
- Blood Vessels
- Brain
- Cerebral Amyloid Angiopathy
- Female
- Genotype
- Humans
- Image Processing, Computer-Assisted