Article
A molecular link between activation and inactivation of sodium channels.
The Journal of general physiology - 1 Oct 1995
O'Leary M E, Chen L Q, Kallen R G, Horn R
Abstract excerpt
A pair of tyrosine residues, located on the cytoplasmic linker between the third and fourth domains of human heart sodium channels, plays a critical role in the kinetics and voltage dependence of inactivation. Substitution of these residues by glutamine (Y1494Y1495/QQ), but not phenylalanine, nearly eliminates the voltage dependence of the inactivation time constant measured from the decay of macroscopic current...
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