Article
Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels.
The American journal of physiology - 1 Dec 1998
Nagatomo T, Fan Z, Ye B, Tonkovich G S, January C T, Kyle J W, Makielski J C
Abstract excerpt
Na+ current (INa) through wild-type human heart Na+ channels (hH1) is important for normal cardiac excitability and conduction, and it participates in the control of repolarization and refractoriness. INa kinetics depend strongly on temperature, but INa for hH1 has been studied previously only at room temperature. We characterized early INa (the peak and initial decay) and late INa of the wild-type hH1 channel...
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