Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels.

doi:10.1152/ajpheart.1998.275.6.H2016

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Article

Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels.

The American journal of physiology - 1 Dec 1998

Nagatomo T, Fan Z, Ye B, Tonkovich G S, January C T, Kyle J W, Makielski J C

Abstract excerpt

Na+ current (INa) through wild-type human heart Na+ channels (hH1) is important for normal cardiac excitability and conduction, and it participates in the control of repolarization and refractoriness. INa kinetics depend strongly on temperature, but INa for hH1 has been studied previously only at...

Topics

Cell Line
Electric Conductivity
Homeostasis
Humans
Kinetics
Long QT Syndrome
Mutation
Myocardium
Reaction Time
Sodium Channels
Temperature
Time Factors

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