Article
Cross talk between activation and slow inactivation gates of Shaker potassium channels.
The Journal of general physiology - 1 Nov 2006
Panyi Gyorgy, Deutsch Carol
Abstract excerpt
This study addresses the energetic coupling between the activation and slow inactivation gates of Shaker potassium channels. To track the status of the activation gate in inactivated channels that are nonconducting, we used two functional assays: the accessibility of a cysteine residue engineered into the protein lining the pore cavity (V474C) and the liberation by depolarization of a Cs(+) ion trapped behind the...
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