Article
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
Science (New York, N.Y.) - 2 Nov 1990
Moorman J R, Kirsch G E, Brown A M, Joho R H
Abstract excerpt
Voltage-gated sodium channels are transmembrane proteins of approximately 2000 amino acids and consist of four homologous domains (I through IV). In current topographical models, domains III and IV are linked by a highly conserved cytoplasmic sequence of amino acids. Disruptions of the III-IV lin...
Topics
- Amino Acid Sequence
- Cytoplasm
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Sodium Channels
- Structure-Activity Relationship