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Article

Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.

Science (New York, N.Y.) - 2 Nov 1990

Moorman J R, Kirsch G E, Brown A M, Joho R H

Abstract excerpt

Voltage-gated sodium channels are transmembrane proteins of approximately 2000 amino acids and consist of four homologous domains (I through IV). In current topographical models, domains III and IV are linked by a highly conserved cytoplasmic sequence of amino acids. Disruptions of the III-IV linker by cleavage or antibody binding slow inactivation, the depolarization-induced closed state characteristic of sodium...

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PMID: 2173138
DOI: 10.1126/science.2173138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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