Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.

doi:10.1161/01.res.75.1.114

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Article

Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.

Circulation research - 1 Jul 1994

Hartmann H A, Tiedeman A A, Chen S F, Brown A M, Kirsch G E

Abstract excerpt

Na+ channel inactivation, a critical determinant of refractoriness, differs in cardiomyocytes and neurons. In rat brain type IIa (rB2a) Na+ channels, a critical residue in the cytoplasmic linker between domains III and IV regulates fast inactivation such that a Phe-->Gln substitution (F1489Q) inh...

Topics

Amino Acid Sequence
Electrophysiology
Genetic Linkage
Humans
Ion Channel Gating
Kinetics
Models, Cardiovascular
Molecular Sequence Data
Mutation
Myocardium
Sodium Channels

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