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Article

Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.

Circulation research - 1 Jul 1994

Hartmann H A, Tiedeman A A, Chen S F, Brown A M, Kirsch G E

Abstract excerpt

Na+ channel inactivation, a critical determinant of refractoriness, differs in cardiomyocytes and neurons. In rat brain type IIa (rB2a) Na+ channels, a critical residue in the cytoplasmic linker between domains III and IV regulates fast inactivation such that a Phe-->Gln substitution (F1489Q) inhibits inactivation by at least 85%. Since this residue is conserved in voltage-gated Na+ channels, we tested whether...

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Identifiers

PMID: 8013069
DOI: 10.1161/01.res.75.1.114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.PMID 8013069Read ↗

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