Article
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients.
Nature medicine - 1 Feb 1996
Liu B, Parsons R, Papadopoulos N, Nicolaides N C, Lynch H T, Watson P, Jass J R, Dunlop M, Wyllie A, Peltomäki P, de la Chapelle A, Hamilton S R, Vogelstein B, Kinzler K W
Abstract excerpt
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by the early onset of colorectal cancer and linked to germline defects in at least four mismatch repair genes. Although much has been learned about the molecular pathogenesis of this disease, questions related to effective presymptomatic diagnosis are largely unanswered because of its genetic complexity. In this...
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