The genetics of hereditary non-polyposis colorectal cancer.

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition accounting for 3% to 5% of all colorectal cancer. HNPCC is caused by germline mutations in the mismatch repair system and is recognized by a characteristic clinical phenotype as well as a hallmark of the tumors termed "microsatellite instability." Microsatellite instability serves as a molecular fingerprint for defective mismatch...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Colorectal Neoplasms, Hereditary Nonpolyposis
• Share to Genetic Predisposition to Disease