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Article

The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications.

Annals of internal medicine - 1 Apr 2003

Chung Daniel C, Rustgi Anil K

Abstract excerpt

Basic studies of DNA replication and repair have provided surprising and pivotal insights into a novel pathway of tumorigenesis. Defects in the DNA mismatch repair process dramatically increase the risk for specific types of cancer because of instability in microsatellite DNA sequences. A germline mutation in either the hMSH2 or hMLH1 mismatch repair gene results in the hereditary nonpolyposis colorectal cancer...

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Share to Base Pair Mismatch
Share to Colorectal Cancer Screening and Detection
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12667026
DOI: 10.7326/0003-4819-138-7-200304010-00012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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