Article
Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects.
Biochimica et biophysica acta - 31 May 1999
Bocker T, Rüschoff J, Fishel R
Abstract excerpt
Hereditary non-polyposis colorectal carcinoma accounts for 5-13% of all colorectal carcinomas and is inherited in a dominant fashion. Two different forms can be distinguished. Type I is restricted to colorectal cancers, whereas type II patients acquire acolorectal, endometrial, gastric, small intestinal and transitional carcinomas of the upper urinary tract. Germline mutations in the human mismatch repair genes...
Topics
- Adaptor Proteins, Signal Transducing
- Base Pair Mismatch
- Carrier Proteins
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA, Neoplasm
- DNA-Binding Proteins
- Genetic Testing
- Germ-Line Mutation
- Guidelines as Topic