The genetics of HNPCC: application to diagnosis and screening.

doi:10.1016/j.critrevonc.2005.11.001

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Article

The genetics of HNPCC: application to diagnosis and screening.

Critical reviews in oncology/hematology - 1 Jun 2006

Abdel-Rahman Wael M, Mecklin Jukka-Pekka, Peltomäki Päivi

Abstract excerpt

Hereditary nonpolyposis colorectal cancer syndrome (HNPCC; Lynch Syndrome) is the most common form of hereditary colorectal cancers. Predisposed individuals have increased lifetime risk of developing colorectal, endometrial and other cancers. The syndrome is primarily due to heterozygous germline mutations in one of the mismatch repair genes; mainly MLH1, MSH2, MSH6 and PMS2. The resulting mismatch repair...

Topics

Animals
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
Genes, Neoplasm
Genetic Predisposition to Disease
Genetic Testing
Genomic Instability
Humans
Mutation
Pedigree
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 16434208
DOI: 10.1016/j.critrevonc.2005.11.001

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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