Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive genetic analysis of seven large families with mismatch repair proficient colorectal cancer.

Genes, chromosomes & cancer - 1 Jun 2010

Middeldorp Anneke, Jagmohan-Changur Shantie C, van der Klift Heleen M, van Puijenbroek Marjo, Houwing-Duistermaat Jeanine J, Webb Emily, Houlston Richard, Tops Carli, Vasen Hans F A, Devilee Peter, Morreau Hans, van Wezel Tom, Wijnen Juul

Abstract excerpt

Approximately 40% of colorectal cancer (CRC) families with a diagnosis of hereditary nonpolyposis CRC on the basis of clinical criteria are not a consequence of mismatch repair (MMR) deficiency. Such families provide supporting evidence for the existence of a hitherto unidentified highly penetrant gene mutation. To gain further understanding of MMR-competent familial colorectal cancer (FCC), we studied seven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Chromosomes, Human, Pair 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to DNA Copy Number Variations

Share to DNA Mismatch Repair

Share to Family Health

Share to Histocytochemistry

Share to Linkage Disequilibrium

Source

Identifiers

PMID: 20222047
DOI: 10.1002/gcc.20763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive genetic analysis of seven large families with mismatch repair proficient colorectal cancer.PMID 20222047Read ↗

Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients.Semantic proximity Read ↗

The genetics of hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

Molecular Analysis of Colorectal Cancer Tumors from Patients with Mismatch Repair–Proficient Hereditary Nonpolyposis Colorectal Cancer Suggests Novel Carcinogenic PathwaysSemantic proximity Read ↗

Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X.Semantic proximity Read ↗

Deciphering the genetics of hereditary non-syndromic colorectal cancer.Semantic proximity Read ↗

Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives.Semantic proximity Read ↗

Comprehensive molecular characterisation of hereditary non-polyposis colorectal tumours with mismatch repair proficiency.Semantic proximity Read ↗

Genome-wide linkage analysis and tumoral characterization reveal heterogeneity in familial colorectal cancer type X.Semantic proximity Read ↗

Genetic heterogeneity and unmapped genes for colorectal cancer.Semantic proximity Read ↗

Clues to the pathogenesis of familial colorectal cancer.Semantic proximity Read ↗

Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of <i>BMPR1A</i> loss of functionSemantic proximity Read ↗

Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.