DNA mismatch repair gene mutations in human cancer.

doi:10.1289/ehp.105-1470030

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Article

DNA mismatch repair gene mutations in human cancer.

Environmental health perspectives - 1 Jun 1997

Peltomäki P

Abstract excerpt

A new pathogenetic mechanism leading to cancer has been delineated in the past 3 years when human homologues of DNA mismatch repair (MMR) genes have been identified and shown to be involved in various types of cancer. Germline mutations of MMR genes cause susceptibility to a hereditary form of co...

Topics

Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
Humans
Microsatellite Repeats
Mutation

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