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Article

Cancer risk associated with germline DNA mismatch repair gene mutations

1 Jan 1997

Abstract excerpt

The autosomal dominant syndrome of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is due to germline DNA mismatch repair gene mutations in most cases. However, the penetrance of such mutations outwith classical HNPCC kindreds is unknown because families studied to date have been specifically selected for research purposes. Using a population-based strategy, we have calculated the lifetime cancer risk...

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PMID: 9002677
DOI: 10.1093/hmg/6.1.105

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