Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Approaches to diagnose DNA mismatch repair gene defects in cancer.

DNA repair - 1 Feb 2016

Peña-Diaz Javier, Rasmussen Lene Juel

Abstract excerpt

The DNA repair pathway mismatch repair (MMR) is responsible for the recognition and correction of DNA biosynthetic errors caused by inaccurate nucleotide incorporation during replication. Faulty MMR leads to failure to address the mispairs or insertion deletion loops (IDLs) left behind by the replicative polymerases and results in increased mutation load at the genome. The realization that defective MMR leads to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Research
Share to DNA
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Protein Stability

Source

Identifiers

PMID: 26708048
DOI: 10.1016/j.dnarep.2015.11.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Approaches to diagnose DNA mismatch repair gene defects in cancer.PMID 26708048Read ↗

Update on Hereditary Colorectal Cancer.Semantic proximity Read ↗

DNA mismatch repair proteins: scientific update and practical guide.Semantic proximity Read ↗

Evolving approach and clinical significance of detecting DNA mismatch repair deficiency in colorectal carcinoma.Semantic proximity Read ↗

Role of DNA mismatch repair defects in the pathogenesis of human cancer.Semantic proximity Read ↗

Mismatch repair deficient colorectal cancer in the era of personalized treatment.Semantic proximity Read ↗

Deficient mismatch repair: Read all about it (Review)Semantic proximity Read ↗

DNA mismatch repair gene mutations in human cancer.Semantic proximity Read ↗

Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future.Semantic proximity Read ↗

Mismatch Repair Status Characterization in Oncologic Pathology: Taking Stock of the Real-World PossibilitiesSemantic proximity Read ↗

A series of reviews in familial cancer: genetic cancer risk in context variants of uncertain significance in MMR genes: which procedures should be followed?Semantic proximity Read ↗

DNA mismatch repair: molecular mechanism, cancer, and ageing.Semantic proximity Read ↗

Consequences of testing for mismatch repair deficiency of colorectal cancer in clinical practice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.