Molecular genetics of hereditary nonpolyposis colorectal cancer.

doi:10.1111/j.1749-6632.2000.tb06700.x

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Article

Molecular genetics of hereditary nonpolyposis colorectal cancer.

Annals of the New York Academy of Sciences - 1 Jun 2000

Boland C R

Abstract excerpt

The initial paradigm developed for colorectal carcinogenesis was derived from the observation that these tumors suffer a large number of chromosomal losses. This phenomenon results from unbalanced mitoses, and to date there is no clear explanation for this type of genomic instability. In 1993, a second type of genomic instability was detected and linked to 12-15% of sporadic tumors, as well as 90% or more of the...

Topics

Adaptor Proteins, Signal Transducing
Carrier Proteins
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Humans
MutL Protein Homolog 1
MutS Homolog 2 Protein
Mutation
Neoplasm Proteins
Nuclear Proteins
Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 10911905
DOI: 10.1111/j.1749-6632.2000.tb06700.x

Provenance

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