Article
A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro.
European journal of immunology - 1 Dec 1995
Wu H, Pelkonen E, Knuutila S, Kaartinen M
Abstract excerpt
The functional immunoglobulin (Ig) genes of B lymphocytes undergo somatic mutations during immune responses. These mutations modify the antigen binding site of the immunoglobulins, thereby enhancing the average affinity of the antibodies produced. The molecular mechanism underlying these B cell h...
Topics
- Amino Acid Sequence
- Apoptosis
- B-Lymphocytes
- Base Sequence
- Genes, Immunoglobulin
- Humans
- Lymphoma, Follicular
- Molecular Sequence Data
- Mutation
- Tumor Cells, Cultured