Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro.

Abstract excerpt

The increased affinity of memory antibody responses is due largely to the generation and selection of memory B cells that accumulate somatic mutations after initial antigenic stimulation. Further affinity maturation and mutation also accompany subsequent immunizations. Previous studies have suggested that, like primary antibody-forming cell (AFC) clones, secondary AFC do not accumulate further mutations and,...

Topics

• Amino Acid Sequence
• Animals
• Antibody Formation
• B-Lymphocyte Subsets
• Base Sequence
• Cells, Cultured
• Immunologic Memory
• Lymphocyte Subsets
• Mice
• Molecular Sequence Data
• Mutation