Somatic hypermutation and B cell receptor selection in normal and transformed human B cells.

doi:10.1111/j.1749-6632.2003.tb06046.x

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Article

Somatic hypermutation and B cell receptor selection in normal and transformed human B cells.

Annals of the New York Academy of Sciences - 1 Apr 2003

Küppers Ralf

Abstract excerpt

From the beginning to the end, the life of B cells is dominated by selection of the cells for expression of an appropriate antigen receptor. However, recent studies revealed that there are several diseases in the human where B cells lost their dependence on a B cell receptor (BCR). In classic Hod...

Topics

B-Lymphocytes
Humans
Mutation
Receptors, Antigen, B-Cell
Reed-Sternberg Cells
Selection, Genetic

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