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Article

Somatic hypermutation and B cell receptor selection in normal and transformed human B cells.

Annals of the New York Academy of Sciences - 1 Apr 2003

Küppers Ralf

Abstract excerpt

From the beginning to the end, the life of B cells is dominated by selection of the cells for expression of an appropriate antigen receptor. However, recent studies revealed that there are several diseases in the human where B cells lost their dependence on a B cell receptor (BCR). In classic Hodgkin's lymphoma, the lymphoma cells presumably derive from "crippled" germinal center (GC) B cells that acquired...

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Identifiers

PMID: 12727637
DOI: 10.1111/j.1749-6632.2003.tb06046.x

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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