Article
Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.
The Journal of experimental medicine - 1 Oct 1992
Zelenetz A D, Chen T T, Levy R
Abstract excerpt
The genesis of human follicular lymphoma (FL) is a multistep process. The initial event is thought to be the chromosomal translocation t(14;18)(q32;q21) juxtaposing the bcl-2 proto-oncogene with the immunoglobulin (Ig) H chain locus joining segment (JH) as an error of D-J or V-D joining in the pr...
Topics
- Base Sequence
- Blotting, Southern
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 18
- Cloning, Molecular
- DNA, Neoplasm
- Gene Rearrangement
- Genomic Library
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Lymphoma, Follicular
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Proto-Oncogene Mas
- Proto-Oncogene Proteins