Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.

The Journal of experimental medicine - 1 Oct 1992

Zelenetz A D, Chen T T, Levy R

Abstract excerpt

The genesis of human follicular lymphoma (FL) is a multistep process. The initial event is thought to be the chromosomal translocation t(14;18)(q32;q21) juxtaposing the bcl-2 proto-oncogene with the immunoglobulin (Ig) H chain locus joining segment (JH) as an error of D-J or V-D joining in the pre-B cell. However, FL is recognized clinically as a tumor of surface Ig (sIg)-positive B cells with morphologic and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Southern
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1402658
DOI: 10.1084/jem.176.4.1137
PMCID: PMC2119381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.PMID 1402658Read ↗

Clonal selection in the bone marrow involvement of follicular lymphoma.Semantic proximity Read ↗

Cell migration patterns and ongoing somatic mutations in the progression of follicular lymphoma.Semantic proximity Read ↗

Clonal evolution of a follicular lymphoma: evidence for antigen selection.Semantic proximity Read ↗

High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution.Semantic proximity Read ↗

Somatic mutation of the 5' noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma.Semantic proximity Read ↗

Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones.Semantic proximity Read ↗

Follicular lymphomas contain a clonally linked but phenotypically distinct neoplastic B-cell population in the interfollicular zone.Semantic proximity Read ↗

Clonal Evolution in t(14;18)-Positive Follicular Lymphoma, Evidence for Multiple Common Pathways, and Frequent Parallel Clonal EvolutionSemantic proximity Read ↗

Critical influences on the pathogenesis of follicular lymphoma.Semantic proximity Read ↗

The genetic variability of the VH genes in follicular lymphoma: the impact of the hypermutation mechanism.Semantic proximity Read ↗

Molecular insights into the immunopathogenesis of follicular lymphoma.Semantic proximity Read ↗

Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analysesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.